3-Bromo-6-chloroimidazo[1,2-β]pyridazine
3-Bromo-6-chloroimidazo[1,2-b]pyridazine
CAS: 13526-66-4
Molecular Formula: C6H3BrClN3
3-Bromo-6-chloroimidazo[1,2-β]pyridazine - Names and Identifiers
| Name | 3-Bromo-6-chloroimidazo[1,2-b]pyridazine |
| Synonyms | 3-bromo-6-chloroimidazo[1,2-a]pyridine -Bromo-6-chloroimidazo[1,2-b]pyridazine 6-Chloro-3-broMoiMidazo[1,2-a]pyridazine 3-Bromo-6-chloroimidazo[1,2-β]pyridazine 3-Bromo-6-chloroimidazo[1,2-b]pyridazine IMidazo[1,2-b]pyridazine, 3-broMo-6-chloro- |
| CAS | 13526-66-4 |
| InChI | InChI=1/C6H3BrClN3/c7-4-3-9-6-2-1-5(8)10-11(4)6/h1-3H |
3-Bromo-6-chloroimidazo[1,2-β]pyridazine - Physico-chemical Properties
| Molecular Formula | C6H3BrClN3 |
| Molar Mass | 232.47 |
| Density | 2.03 |
| Melting Point | 156 °C |
| Appearance | Solid |
| pKa | 0.73±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.768 |
| MDL | MFCD09027274 |
3-Bromo-6-chloroimidazo[1,2-β]pyridazine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
3-Bromo-6-chloroimidazo[1,2-β]pyridazine - Introduction
3-Bromo-6-chloroimidazo [1,2-b] pyridazine, chemical formula C8H4BrClN3, is an aromatic compound containing nitrogen, chlorine and bromine atoms. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 3-Bromo-6-chloroimidazo [1,2-b] pyridazine is a colorless to light yellow crystal or powdery solid.
-Melting point: about 280-285 degrees Celsius.
-Solubility: Poor solubility in solvents, soluble in hot dichloromethane and other chlorinated solvents.
Use:
3-Bromo-6-chloroimidazo [1,2-b] pyridazine is often used as an intermediate in the synthesis of organic compounds. It can be used to synthesize compounds such as drugs, disinfectants, dyes and pesticides. Because of its wide range of uses, it has certain application prospects in the fields of medicine, agriculture and chemical industry.
Preparation Method:
The method for preparing 3-bromo-6-chloroimidazo [1,2-b] pyridazine generally involves a chloro-bromo substitution reaction at the para-position. The specific synthetic procedure may vary depending on the desired compound and reaction conditions. A commonly used method is to react 2-bromo-3, 5-dichloroimidazole with nitrosodifluoromethane to give 3-bromo-2-{2-[[(trifluoromethyl)sulfonyl]oxy]ethyl}-6-chloroimidazo [1,2-b] pyridazine, followed by reduction, work-up and crystallization steps to give the target compound.
Safety Information:
-3-Bromo-6-chloroimidazo [1,2-b] pyridazine is a hazardous chemical and requires compliance with relevant safety procedures.
-Use personal protective equipment such as protective gloves, masks, goggles and protective clothing during handling and storage. Avoid contact with skin, eyes and respiratory tract.
-Avoid inhaling dust, and operate in a well-ventilated place to avoid dust.
-Follow local regulations and procedures during handling and disposal to avoid environmental pollution.
-In storage, it should be kept in a dry, cool place, away from fire and flammable materials.
Nature:
-Appearance: 3-Bromo-6-chloroimidazo [1,2-b] pyridazine is a colorless to light yellow crystal or powdery solid.
-Melting point: about 280-285 degrees Celsius.
-Solubility: Poor solubility in solvents, soluble in hot dichloromethane and other chlorinated solvents.
Use:
3-Bromo-6-chloroimidazo [1,2-b] pyridazine is often used as an intermediate in the synthesis of organic compounds. It can be used to synthesize compounds such as drugs, disinfectants, dyes and pesticides. Because of its wide range of uses, it has certain application prospects in the fields of medicine, agriculture and chemical industry.
Preparation Method:
The method for preparing 3-bromo-6-chloroimidazo [1,2-b] pyridazine generally involves a chloro-bromo substitution reaction at the para-position. The specific synthetic procedure may vary depending on the desired compound and reaction conditions. A commonly used method is to react 2-bromo-3, 5-dichloroimidazole with nitrosodifluoromethane to give 3-bromo-2-{2-[[(trifluoromethyl)sulfonyl]oxy]ethyl}-6-chloroimidazo [1,2-b] pyridazine, followed by reduction, work-up and crystallization steps to give the target compound.
Safety Information:
-3-Bromo-6-chloroimidazo [1,2-b] pyridazine is a hazardous chemical and requires compliance with relevant safety procedures.
-Use personal protective equipment such as protective gloves, masks, goggles and protective clothing during handling and storage. Avoid contact with skin, eyes and respiratory tract.
-Avoid inhaling dust, and operate in a well-ventilated place to avoid dust.
-Follow local regulations and procedures during handling and disposal to avoid environmental pollution.
-In storage, it should be kept in a dry, cool place, away from fire and flammable materials.
Last Update：2024-04-09 19:05:46
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View History
3-Bromo-6-chloroimidazo[1,2-β]pyridazine
[(5R)-5-(1,2-dihydroxyethyl)-4-hydroxy-5-methyl-2-oxo-3-furyl]oxysodium hydrate
(3-BROMO-4-FLUORO-PHENYL)-METHANOL
4-(methylsulfanyl)-N-[4-(4-pyridinylmethyl)phenyl]benzenesulfonamide
[(5R)-5-(1,2-dihydroxyethyl)-4-hydroxy-5-methyl-2-oxo-3-furyl]oxysodium hydrate
(3-BROMO-4-FLUORO-PHENYL)-METHANOL
4-(methylsulfanyl)-N-[4-(4-pyridinylmethyl)phenyl]benzenesulfonamide